2021 MSUFCU Grand Prize Award for the Lyman Briggs Research Showcase
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FDA Approved Drug Bicalutamide Rescues Male Mice from Kennedy’s Disease Mackenzie Greene, 3rd year |
Abstract
Kennedy’s Disease (KD) is a neurodegenerative disorder caused by a polyglutamine expansion, or CAG repeat, in the Androgen Receptor (AR) gene. This disease affects only males, usually emerges mid-life, and is characterized by marked deficits in muscle strength and coordination. Male mice with the KD allele develop muscle weakness around puberty as testosterone levels surge, suggesting that levels of testosterone may contribute to disease development in mice with mutated AR.
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