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Computational Experiments to Investigate Biological Questions Using ms Maria Pacifico, 2nd year |
Abstract
Programs have been developed for comparative genomics and the creation of phylogenetic trees using algorithms. Within the program ms (Hudson, 2002), we are studying population genetics and phylogenetics. Ms generates a simple sample model according to the Wright-Fisher neutral model based on chosen parameters.
Parameters may include recombination, population size, migration, and gene conversion. For this experiment, we are using ms and seq-gen (Rambaut & Grassly, 1997) to examine the distances of the random outputs and analyzing the differences. Working with bioinformatics can help further advancements in biomedicine and our understanding of evolutionary biology since programs like ms and seq-gen are continuously being updated to be more accurate and efficient.
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